Journal article
Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: Results from diverse cohorts
M Mamtani, H Kulkarni, G Wong, JM Weir, CK Barlow, TD Dyer, L Almasy, MC Mahaney, AG Comuzzie, DC Glahn, DJ Magliano, P Zimmet, J Shaw, S Williams-Blangero, R Duggirala, J Blangero, PJ Meikle, JE Curran
Lipids in Health and Disease | BIOMED CENTRAL LTD | Published : 2016
Abstract
Background: Detection of type 2 diabetes (T2D) is routinely based on the presence of dysglycemia. Although disturbed lipid metabolism is a hallmark of T2D, the potential of plasma lipidomics as a biomarker of future T2D is unknown. Our objective was to develop and validate a plasma lipidomic risk score (LRS) as a biomarker of future type 2 diabetes and to evaluate its cost-effectiveness for T2D screening. Methods: Plasma LRS, based on significantly associated lipid species from an array of 319 lipid species, was developed in a cohort of initially T2D-free individuals from the San Antonio Family Heart Study (SAFHS). The LRS derived from SAFHS as well as its recalibrated version were validated..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported in part by National Institutes of Health (NIH) grants R01 DK082610 and R01 DK079169; by NIH grants R01 HL045522, R01 MH078143, R01 MH078111 and R01 MH083824 (SAFHS data collection) and by NIH grant R37 MH059490 (analytical methods and software used). The AT&T Genomics Computing Center supercomputing facilities used for this work were supported in part by a gift from the AT&T Foundation with support from the National Center for Research Resources Grant Number S10 RR029392. This investigation was conducted in facilities constructed with support from Research Facilities Improvement Program grants C06 RR013556 and C06 RR017515 from the National Center for Research Resources of the National Institutes of Health. The AusDiab cohort was supported by funding from the Dairy Health and Nutrition Consortium, Australia, The National Health and Medical Research Council of Australia #233200 and #1007544, the OIS Program of the Victorian Government, Australia and by Award Number 1R01DK088972-01 from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA.